Artikel

Pengaruh fraksi polifenol Gendarussa Vulgaris Nees pada penurunan aktivitas hialuronidase spermatozoa mencit melalui uji fertilisasi in vitro :

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Penilaian

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Proving ethnomedicinal information of Gendarussa Vulgaris Nees. as male contraceptive is one of developing effort of Indonesian traditional drugs. Some researches have been done on various extracts or fraction of G. vulgarisleaf, all to reveal the mechanism of action of active compounds againts animal beside elucidating its sctive compounds. In this research, n-butanol fraction that known to contain flavonoid [polyphenol] by HPLC-DAD was used. Male mice was used as experimental animals, doses with 15 mg/20 g b.w. and 30 mg/20 g b.w. p.o. once a day for 55 days. Decrease of hyaluronidase activity of mice spermatozoa was shown by inhibition of mice spermatozoa penetration in vitro fertilization process after 7 hours incubation. Result shown that administration of the polyphenol fraction, could inhibition mice spermatozoa penetration IVF shown by no zygotedeveloped. Further more also put identified that no dispersion of cumulus oophorus or granulse cell.yo.

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Informasi Detail

Judul Seri

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No. Panggil

J 613 Med

Penerbit

: .,

Deskripsi Fisik

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Bahasa

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

Medika Eksakta4, Nomor 1, April 200317-28

Subjek

Gendarussa Vulgaris Nees
Hyaluronidase Mice Spermatozoa
Flavonoid
Polyphenol
In Vitro Fertilization

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Pernyataan Tanggungjawab

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